⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16645015 | 0.85 | — | — | |
| SCHEMBL25626099 | 0.82 | — | — | |
| SCHEMBL19750447 | 0.80 | — | — | |
| SCHEMBL2924904 | 0.80 | TSHR (0.32) | — | |
| SCHEMBL8776851 | 0.78 | — | — | |
| SCHEMBL16641608 | 0.77 | TSHR (0.33) | — | |
| SCHEMBL18601932 | 0.74 | — | — | |
| SCHEMBL16645233 | 0.72 | TSHR (0.30) | — | |
| SCHEMBL19443251 | 0.71 | TDP1 (0.36) | — | |
| SCHEMBL20180938 | 0.71 | TSHR (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9849191-B2 | Protein-polymer-drug conjugates | MERSANA THERAPEUTICS, INC. (US) | 2017-12-26 | — | — | US | disclosed |
| EP-2717916-B1 | PROTEIN-POLYMER-DRUG CONJUGATES | MERSANA THERAPEUTICS INC (US) | 2017-03-08 | — | — | EP | disclosed |
| US-9555112-B2 | Monoclonal antibodies against HER2 epitope and methods of use thereof | MERSANA THERAPEUTICS, INC. (US) | 2017-01-31 | — | — | US | disclosed |
| US-20160022829-A1 | TUBULYSIN COMPOUNDS AND CONJUGATES THEREOF | MERSANA THERAPEUTICS, INC. | 2016-01-28 | — | — | US | disclosed |
| US-20150366987-A1 | MONOCLONAL ANTIBODIES AGAINST HER2 EPITOPE AND METHODS OF USE THEREOF | MERSANA THERAPEUTICS, INC. | 2015-12-24 | — | — | US | disclosed |
| US-20150104407-A1 | PROTEIN-POLYMER-DRUG CONJUGATES | MERSANA THERAPEUTICS, INC. | 2015-04-16 | — | — | US | disclosed |