Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | CPT2 | P23786 | 3/20 | 0.36 |
| ▸ | CPT1A | P50416 | 3/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634834 | 0.92 | NAMPT (0.75) | NAMPTCPT2CPT1AACVR1CHEK1 | |
| SCHEMBL16634780 | 0.78 | NAMPT (0.67) | NAMPTCPT2CPT1AACVR1CHEK1 | |
| SCHEMBL16634691 | 0.77 | NAMPT (0.77) | NAMPTACVR1ALDH1A1KMT2A | |
| SCHEMBL16634738 | 0.77 | NAMPT (1.00) | NAMPTACVR1CHEK1FLT3ALDH1A1 | |
| SCHEMBL29478194 | 0.77 | NAMPT (1.00) | NAMPTACVR1CHEK1FLT3ALDH1A1 | |
| SCHEMBL16645228 | 0.77 | NAMPT (0.75) | NAMPTACVR1CHEK1FLT3HPGD | |
| SCHEMBL16634820 | 0.77 | NAMPT (0.70) | NAMPTCPT2CPT1AACVR1FLT3 | |
| SCHEMBL16634756 | 0.76 | NAMPT (0.67) | NAMPTCPT2CPT1AACVR1HPGD | |
| SCHEMBL16645229 | 0.76 | NAMPT (0.67) | NAMPTCPT2CPT1AACVR1HPGD | |
| SCHEMBL16634818 | 0.76 | NAMPT (0.76) | NAMPTPRMT5WDR77ACVR1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015054060-A1 | NOVEL PYRIDYLOXYACETYL TETRAHYDROISOQUINOLINE COMPOUNDS USEFUL AS NAMPT INHIBITORS | ELI LILLY AND COMPANY (US) | 2015-04-16 | — | — | WO | disclosed |