Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16837396 | 1.00 | HSD17B10 (0.41) | HSD17B10MEN1KMT2AHSD11B1CHRM1 | |
| SCHEMBL16645317 | 0.92 | HSD17B10 (0.47) | HSD17B10MEN1KMT2AHSD11B1CHRM1 | |
| SCHEMBL12018111 | 0.90 | HSD17B10 (0.48) | HSD17B10SIGMAR1KDM4EALDH1A1S1PR1 | |
| SCHEMBL1142728 | 0.90 | HSD17B10 (0.48) | HSD17B10SIGMAR1KDM4EALDH1A1S1PR1 | |
| SCHEMBL22661894 | 0.90 | HSD17B10 (0.48) | HSD17B10SIGMAR1KDM4EALDH1A1S1PR1 | |
| SCHEMBL10317239 | 0.90 | HSD17B10 (0.48) | HSD17B10SIGMAR1KDM4EALDH1A1S1PR1 | |
| SCHEMBL9119001 | 0.90 | HSD17B10 (0.48) | HSD17B10SIGMAR1KDM4EALDH1A1S1PR1 | |
| Hydrochloric Acid SCHEMBL10316899 | 0.88 | HSD17B10 (0.47) | HSD17B10SIGMAR1KDM4EALDH1A1S1PR1 | |
| SCHEMBL11360386 | 0.88 | HSD17B10 (0.50) | HSD17B10SIGMAR1ALDH1A1S1PR1 | |
| Hydrochloric Acid SCHEMBL10316965 | 0.86 | HSD17B10 (0.48) | HSD17B10SIGMAR1ALDH1A1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3222617-B1 | PSMA-TARGETING COMPOUNDS AND USES THEREOF | UNIV JOHNS HOPKINS (US) | 2022-07-06 | — | — | EP | disclosed |
| WO-2020065045-A1 | LABELED INHIBITORS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA), THEIR USE AS IMAGING AGENTS AND PHARMACEUTICAL AGENTS FOR THE TREATMENT OF PSMA-EXPRESSING CANCERS | Universität Heidelberg (DE) | 2020-04-02 | — | — | WO | disclosed |
| US-9776977-B2 | PSMA-targeting compounds and uses thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-10-03 | — | — | US | disclosed |
| EP-3222617-A1 | PSMA-TARGETING COMPOUNDS AND USES THEREOF | The Johns Hopkins University (US) | 2017-09-27 | — | — | EP | disclosed |
| EP-2408755-B1 | Urea-based peptide compounds useful for detecting inter alia prostate cancer | UNIV JOHNS HOPKINS (US) | 2017-05-03 | — | — | EP | disclosed |
| US-9056841-B2 | PSMA-targeting compounds and uses thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-06-16 | — | — | US | disclosed |
| US-20150104387-A1 | PSMA-TARGETING COMPOUNDS AND USES THEREOF | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150104387-A1 | PSMA-TARGETING COMPOUNDS AND USES THEREOF | FOLH1, KLK3, PSMA2 | HSD17B10 2398/4885MEN1 190/4885KMT2A 2318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.