Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 15/20 | 0.76 |
| ▸ | GRIN2A | Q12879 | 15/20 | 0.76 |
| ▸ | GRIA2 | P42262 | 7/20 | 0.76 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16636664 | 0.91 | GRIN1 (0.78) | GRIN1GRIN2AGRIA2IDH1NLRP3 | |
| SCHEMBL16636747 | 0.89 | GRIN1 (0.84) | GRIN1GRIN2AGRIA2IDH1NLRP3 | |
| SCHEMBL16637712 | 0.87 | GRIN1 (0.75) | GRIN1GRIN2AGRIA2IDH1 | |
| SCHEMBL16645606 | 0.87 | GRIN1 (1.00) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16636986 | 0.85 | GRIN1 (0.69) | GRIN1GRIN2AGRIA2IDH1NLRP3 | |
| SCHEMBL16637149 | 0.85 | GRIN1 (0.68) | GRIN1GRIN2AGRIA2IDH1NLRP3 | |
| SCHEMBL16645615 | 0.82 | GRIN2A (0.63) | GRIN1GRIN2AGRIA2IDH1NLRP3 | |
| SCHEMBL16645478 | 0.80 | GRIN1 (0.77) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16645472 | 0.80 | GRIN1 (0.62) | GRIN1GRIN2AGRIA2IDH1NLRP3 | |
| SCHEMBL16637396 | 0.79 | GRIN2A (0.69) | GRIN1GRIN2AGRIA2IDH1NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |