Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 15/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 15/20 | 0.51 |
| ▸ | GRIA2 | P42262 | 6/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | MPL | P40238 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16645942 | 0.90 | GRIN1 (0.57) | GRIN1GRIN2AGRIA2SCN9A | |
| SCHEMBL17958338 | 0.87 | GRIN1 (0.69) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16645812 | 0.83 | GRIN2A (0.50) | GRIN1GRIN2AGRIA2MPLSCN9A | |
| SCHEMBL16645647 | 0.82 | GRIN2A (0.53) | GRIN1GRIN2AGRIA2CHEK2MPL | |
| SCHEMBL16636460 | 0.80 | GRIN1 (0.77) | GRIN1GRIN2AGRIA2CD38 | |
| SCHEMBL16645639 | 0.78 | GRIN2A (0.50) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16645938 | 0.72 | GRIN1 (0.55) | GRIN1GRIN2AGRIA2MPLCD38 | |
| SCHEMBL16645491 | 0.72 | GRIN1 (0.70) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16645951 | 0.72 | GRIN1 (0.56) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16636640 | 0.71 | GRIN1 (0.78) | GRIN1GRIN2AGRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |