Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A | Q12879 | 18/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 17/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 9/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16645695 | 0.90 | GRIN1 (0.53) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL17958191 | 0.81 | GRIN1 (0.60) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645936 | 0.81 | GRIN1 (0.59) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL20403423 | 0.80 | GRIN1 (0.58) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL17958182 | 0.76 | GRIN1 (0.61) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645746 | 0.76 | GRIN2A (0.51) | GRIN2AGRIN1GRIA2HTTGRIN2D | |
| SCHEMBL16645672 | 0.75 | GRIN2A (0.54) | GRIN2AGRIN1GRIA2GRIN2DGRIN2C | |
| SCHEMBL17958096 | 0.74 | GRIN1 (0.73) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645706 | 0.74 | GRIN1 (0.64) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL20403467 | 0.74 | GRIN1 (0.59) | GRIN2AGRIN1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |