Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 6/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.42 |
| ▸ | CD38 | P28907 | 1/20 | 0.39 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16636982 | 0.86 | GRIN1 (0.58) | GRIN1GRIN2AGRIA2GRM4P2RX7 | |
| SCHEMBL16645938 | 0.86 | GRIN1 (0.55) | GRIN1GRIN2AGRIA2CD38P2RX7 | |
| SCHEMBL16645813 | 0.86 | GRIN1 (0.41) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16645466 | 0.75 | GRIN1 (0.61) | GRIN1GRIN2AGRIA2CD38P2RX7 | |
| SCHEMBL16645803 | 0.75 | GRIN1 (0.46) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16645600 | 0.75 | GRIN1 (0.62) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16645945 | 0.74 | GRIN1 (0.43) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL17958237 | 0.73 | GRIN1 (0.73) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL17958254 | 0.73 | GRIN1 (0.56) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL17958250 | 0.73 | GRIN1 (0.66) | GRIN1GRIN2AGRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |