Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A | Q12879 | 16/20 | 0.60 |
| ▸ | GRIN1 | Q05586 | 15/20 | 0.60 |
| ▸ | GRIA2 | P42262 | 12/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17958180 | 0.92 | GRIN2A (0.60) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL16637168 | 0.84 | GRIN2A (0.66) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL16637050 | 0.83 | GRIN2A (0.64) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL16636830 | 0.83 | GRIN2A (0.68) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL17958276 | 0.83 | GRIN2A (0.62) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL16645969 | 0.82 | GRIN2A (0.64) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL16636616 | 0.80 | GRIN2A (0.66) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL16636443 | 0.80 | GRIN2A (0.66) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL16636695 | 0.79 | GRIN2A (0.62) | GRIN2AGRIN1GRIA2MAPTPOLB | |
| SCHEMBL16636662 | 0.79 | GRIN2A (0.65) | GRIN2AGRIN1GRIA2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055315-B1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | HOFFMANN LA ROCHE (CH) | 2018-07-25 | — | — | EP | disclosed |
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |