Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A | Q12879 | 9/20 | 0.65 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.65 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17958342 | 0.93 | GRIN2A (0.64) | GRIN2AGRIN1GRIA2MAPTRXFP1 | |
| SCHEMBL20403496 | 0.91 | GRIN2A (0.62) | GRIN2AGRIN1GRIA2MAPTRXFP1 | |
| SCHEMBL16638042 | 0.91 | GRIN2A (0.78) | GRIN2AGRIN1GRIA2MAPTRXFP1 | |
| SCHEMBL16637154 | 0.89 | GRIN2A (0.64) | GRIN2AGRIN1GRIA2MAPTRXFP1 | |
| SCHEMBL21983266 | 0.84 | GRIN2A (0.59) | GRIN2AGRIN1GRIA2MAPTRXFP1 | |
| SCHEMBL16645554 | 0.84 | GRIN2A (0.81) | GRIN2AGRIN1GRIA2MAPTRXFP1 | |
| SCHEMBL16645553 | 0.79 | GRIN2A (1.00) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16637270 | 0.78 | GRIN2A (0.75) | GRIN2AGRIN1GRIA2MAPTRXFP1 | |
| SCHEMBL17958184 | 0.78 | GRIN2A (0.54) | GRIN2AGRIN1GRIA2MAPTRXFP1 | |
| SCHEMBL16645859 | 0.77 | GRIN2A (0.82) | GRIN2AGRIN1GRIA2MAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |