Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.75 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.75 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.75 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.75 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.75 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.75 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.75 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.75 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.75 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16644092 | 0.90 | HDAC6 (0.73) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL19710836 | 0.87 | HDAC6 (0.69) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL19710750 | 0.87 | HDAC6 (0.66) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL2225248 | 0.86 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| Ricolinostat SCHEMBL574580 | 0.86 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL21707466 | 0.85 | HDAC6 (0.98) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL21574250 | 0.84 | HDAC6 (0.67) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL18542603 | 0.83 | HDAC6 (0.64) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL16646755 | 0.83 | HDAC6 (0.76) | HDAC6HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL2226158 | 0.82 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017184774-A1 | HDAC INHIBITORS, ALONE OR IN COMBINATION WITH BTK INHIBITORS, FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA | ACETYLON PHARMACEUTICALS, INC. (US) | 2017-10-26 | — | — | WO | disclosed |
| WO-2017075192-A1 | HDAC INHIBITORS FOR THE TREATMENT OF DIABETIC PERIPHERAL NEUROPATHY | ACETYLON PHARMACEUTICALS, INC. (US) | 2017-05-04 | — | — | WO | disclosed |
| WO-2016200930-A9 | METHODS OF MAKING PROTEIN DEACETYLASE INHIBITORS | ACETYLON PHARMACEUTICALS, INC. (US) | 2017-02-23 | — | — | WO | disclosed |
| WO-2015054197-A1 | HDAC INHIBITORS, ALONE OR IN COMBINATION WITH BTK INHIBITORS, FOR TREATING NON-HODGKIN'S LYMPHOMA | ACETYLON PHARMACEUTICALS, INC. (US) | 2015-04-16 | — | — | WO | disclosed |