Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.57 |
| ▸ | CRYZ | Q08257 | 1/20 | 0.57 |
| ▸ | VAT1 | Q99536 | 1/20 | 0.57 |
| ▸ | RTN4 | Q9NQC3 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29765661 | 0.92 | KRAS (0.68) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL16637063 | 0.92 | KRAS (0.68) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL21402204 | 0.89 | KRAS (0.54) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL16647053 | 0.88 | KRAS (0.66) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL16647007 | 0.84 | KRAS (0.62) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23564891 | 0.84 | KRAS (0.54) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL21402224 | 0.83 | KRAS (0.49) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL16647044 | 0.82 | KRAS (0.52) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL18411117 | 0.81 | KRAS (0.58) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL18128627 | 0.81 | KRAS (0.57) | KRASEGFRHMOX2CRYZVAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015054572-A1 | INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC (US) | 2015-04-16 | — | — | WO | disclosed |