Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | GRM8 | O00222 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 5/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9903763 | 0.85 | TAAR1 (0.47) | SLC6A2SLC6A4SLC6A3CACNA1CTAAR1 | |
| SCHEMBL14786542 | 0.84 | GRM8 (0.42) | SLC6A2SLC6A4SLC6A3CACNA1CTAAR1 | |
| SCHEMBL3602797 | 0.84 | PDE2A (0.43) | SLC6A2SLC6A4SLC6A3CACNA1CTAAR1 | |
| SCHEMBL17352715 | 0.84 | GRM8 (0.42) | SLC6A2SLC6A4SLC6A3CACNA1CTAAR1 | |
| SCHEMBL3595268 | 0.84 | PDE2A (0.43) | SLC6A2SLC6A4SLC6A3CACNA1CTAAR1 | |
| SCHEMBL906156 | 0.84 | PDE2A (0.43) | SLC6A2SLC6A4SLC6A3CACNA1CTAAR1 | |
| Hydrochloric Acid SCHEMBL23112722 | 0.82 | GRM8 (0.41) | SLC6A2SLC6A4SLC6A3CACNA1CTAAR1 | |
| SCHEMBL2320826 | 0.82 | PDE2A (0.42) | SLC6A2SLC6A4SLC6A3CACNA1CTAAR1 | |
| SCHEMBL2319194 | 0.82 | PDE2A (0.42) | SLC6A2SLC6A4SLC6A3CACNA1CTAAR1 | |
| SCHEMBL2319191 | 0.82 | PDE2A (0.42) | SLC6A2SLC6A4SLC6A3CACNA1CTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | claimed |