Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.50 |
| ▸ | BTK | Q06187 | 15/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665094 | 0.73 | JAK3 (0.48) | JAK3JAK2 | |
| SCHEMBL1663059 | 0.71 | JAK3 (0.49) | JAK3BTK | |
| SCHEMBL1662386 | 0.70 | PLK4 (0.50) | JAK3BTKJAK2 | |
| SCHEMBL24243369 | 0.68 | JAK3 (0.58) | JAK3BTKJAK2 | |
| SCHEMBL1662830 | 0.68 | JAK3 (0.41) | JAK3BTKJAK2 | |
| SCHEMBL1663028 | 0.67 | JAK3 (0.47) | JAK3BTKJAK2 | |
| SCHEMBL22496490 | 0.67 | JAK3 (1.00) | JAK3BTK | |
| SCHEMBL22496484 | 0.67 | JAK3 (1.00) | JAK3BTK | |
| SCHEMBL1665152 | 0.67 | JAK3 (0.46) | JAK3BTKJAK2 | |
| SCHEMBL1665417 | 0.66 | FLT4 (0.42) | JAK3BTKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491039-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | Cellzome Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |