Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mequinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.84 |
| ▸ | LTA4H | P09960 | 1/20 | 0.84 |
| ▸ | APP | P05067 | 2/20 | 0.73 |
| ▸ | CA12 | O43570 | 1/20 | 0.69 |
| ▸ | CA1 | P00915 | 1/20 | 0.69 |
| ▸ | CA2 | P00918 | 1/20 | 0.69 |
| ▸ | CA7 | P43166 | 1/20 | 0.69 |
| ▸ | CA9 | Q16790 | 1/20 | 0.69 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.69 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.58 |
| ▸ | BCR | P11274 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,4-Dimethoxybenzene SCHEMBL8351066 | 1.00 | ESR2 (0.84) | ESR2LTA4HAPPCA12CA1 | |
| Mequinol SCHEMBL21009 | 1.00 | — | — | |
| Mequinol SCHEMBL1535640 | 1.00 | ESR2 (0.84) | ESR2LTA4HAPPCA12CA1 | |
| Mequinol SCHEMBL28560858 | 0.97 | ESR2 (0.80) | ESR2LTA4HAPPCA12CA1 | |
| Mequinol SCHEMBL2424246 | 0.97 | ESR2 (0.80) | ESR2LTA4HAPPCA12CA1 | |
| Mequinol SCHEMBL29495271 | 0.97 | ESR2 (0.80) | ESR2LTA4HAPPCA12CA1 | |
| Mequinol SCHEMBL28811337 | 0.97 | ESR2 (0.80) | ESR2LTA4HAPPCA12CA1 | |
| Mequinol SCHEMBL16338066 | 0.97 | ESR2 (0.80) | ESR2LTA4HAPPCA12CA1 | |
| Mequinol SCHEMBL20696082 | 0.97 | ESR2 (0.80) | ESR2LTA4HAPPCA12CA1 | |
| Mequinol SCHEMBL1535642 | 0.97 | ESR2 (0.80) | ESR2LTA4HAPPCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0727980-A1 | QUICK-DRYING NAIL COATING COMPOSITION | VALENTY, Vivian B. (US) | 1996-08-28 | — | — | EP | claimed |
| US-5456905-A | Blend of nitrocellulose, photosensitive monomer, photoinitiator, and polymerization inhibitor | ULTRASET LIMITED PARTNERSHIP (US) | 1995-10-10 | — | — | US | claimed |
| US-5435994-A | Quick-drying nail coating method and composition | ULTRASET LIMITED PARTNERSHIP (US) | 1995-07-25 | — | — | US | claimed |
| EP-0727980-A4 | QUICK-DRYING NAIL COATING COMPOSITION | VALENTY VIVIAN B (US) | 1995-03-02 | — | — | EP | claimed |
| WO-1993018733-A1 | QUICK-DRYING NAIL COATING COMPOSITION | VALENTY VIVIAN B (US) | 1993-09-30 | — | — | WO | claimed |
| US-5118495-A | Photoreactive; nitrocellulose, dimethacrylate and/or methacrylate monomer, photoinitiator, polymerization inhibitor | LIFETIME COSMETICS, INC. (US) | 1992-06-02 | — | — | US | claimed |
| CN-113087851-A | Friction-resistant 3D printing photocureable resin and application method thereof | 深圳光华伟业股份有限公司 | 2021-07-09 | — | — | CN | disclosed |
| EP-3706709-A1 | DENTAL COMPOSITION WITH HIGH E-MODULUS | 3M Innovative Properties Company (US) | 2020-09-16 | — | — | EP | disclosed |
| CN-208279531-U | A kind of system based on methacrylic acid and ethylene oxide synthesis hydroxyethyl methacrylate | 江苏三益科技有限公司 | 2018-12-25 | — | — | CN | disclosed |
| EP-3107523-A1 | DENTAL COMPOSITION AND USE THEREOF | 3M Innovative Properties Company (US) | 2016-12-28 | — | — | EP | disclosed |
| EP-3107521-A1 | ADHESIVE BONDING COMPOSITION AND USE THEREOF | 3M Innovative Properties Company (US) | 2016-12-28 | — | — | EP | disclosed |
| EP-3107522-A1 | DENTAL COMPOSITION AND USE THEREOF | 3M Innovative Properties Company (US) | 2016-12-28 | — | — | EP | disclosed |
| CN-103160237-B | Adhesive composite, film-like adhesive, adhesive sheet and connection structural bodies | 日立化成株式会社 | 2016-09-28 | — | — | CN | disclosed |
| EP-0465835-A1 | Anionic living polymers, their derivatives and composition comprising them | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1992-01-15 | — | — | EP | disclosed |
| EP-0445912-A1 | Method for forming printing plates and plate-making element | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1991-09-11 | — | — | EP | disclosed |
| US-5032486-A | Lithography | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1991-07-16 | — | — | US | disclosed |
| EP-0309248-A2 | Acrylated diols | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1989-03-29 | — | — | EP | disclosed |
| US-4557997-A | BINDERS OF AMIDE-AND CARBOXYLIC-CONTAINING ACRYLIC COPOLYMERS; ALKALINE AQUEOUS | FUJI PHOTO FILM CO., LTD. (JP) | 1985-12-10 | — | — | US | disclosed |
| US-4339602-A | Process of preparation of racemic hydroxyarylglycolic acids and novel products resulting therefrom | SOCIETE FRANCAISE HOECHST (FR) | 1982-07-13 | — | — | US | disclosed |
| US-4195030-A | Preparation of monomeric organosilicon esters | BAUSCH & LOMB INCORPORATED (US) | 1980-03-25 | — | — | US | disclosed |