Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Safinamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 6/20 | 0.92 |
| ▸ | MAOA | P21397 | 3/20 | 0.92 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Safinamide SCHEMBL1665721 | 1.00 | MAOB (0.92) | MAOBMAOASCN9A | |
| Safinamide SCHEMBL1665715 | 1.00 | MAOB (0.92) | MAOBMAOASCN9A | |
| Safinamide SCHEMBL2938424 | 1.00 | MAOB (0.92) | MAOBMAOASCN9A | |
| Safinamide SCHEMBL29358128 | 1.00 | MAOB (0.92) | MAOBMAOASCN9A | |
| Safinamide SCHEMBL1672446 | 0.99 | MAOB (0.90) | MAOBMAOASCN9A | |
| Safinamide SCHEMBL1672442 | 0.99 | MAOB (0.90) | MAOBMAOASCN9A | |
| Safinamide SCHEMBL6431388 | 0.96 | MAOB (0.88) | MAOBMAOASCN9A | |
| Safinamide SCHEMBL6431392 | 0.96 | MAOB (0.88) | MAOBMAOASCN9A | |
| Safinamide SCHEMBL194169 | 0.96 | MAOB (1.00) | MAOBMAOASCN9A | |
| Safinamide SCHEMBL69350 | 0.96 | MAOB (1.00) | MAOBMAOASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011047767-A1 | NOVEL POLYMORPHIC FORMS OF (S)-2-[-4-(3-FLUORO-BENZYLOXY)-BENZYLAMINO]-PROPIONAMIDE MESYLATE SALT AND PROCESSES OF MANUFACTURING THEREOF | MERCK PATENT GMBH (DE) | 2011-04-28 | — | — | WO | disclosed |
| EP-2314569-A1 | Novel polymorphic forms of (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide mesylate salt and processes of manufacturing thereof | Merck Patent GmbH (DE) | 2011-04-27 | — | — | EP | disclosed |