Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.84 |
| ▸ | NAMPT | P43490 | 2/20 | 0.69 |
| ▸ | BCHE | P06276 | 1/20 | 0.58 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1334862 | 0.92 | POLB (0.88) | POLBNAMPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL13679756 | 0.92 | POLB (1.00) | POLBNAMPTBCHESMN1; SMN2LMNA | |
| SCHEMBL31044012 | 0.90 | POLB (0.70) | POLBNAMPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL8202632 | 0.89 | NAMPT (0.73) | POLBNAMPTBCHESMN1; SMN2LMNA | |
| SCHEMBL2056382 | 0.88 | NAMPT (0.76) | POLBNAMPTBCHESMN1; SMN2RAB9A | |
| SCHEMBL13611978 | 0.85 | NAMPT (0.64) | POLBNAMPTBCHESMN1; SMN2LMNA | |
| SCHEMBL2054657 | 0.85 | MEN1 (0.71) | POLBNAMPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL31043979 | 0.85 | POLB (0.63) | POLBNAMPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL1665313 | 0.84 | POLB (0.67) | POLBNAMPTLMNARAB9ANPC1 | |
| SCHEMBL31043775 | 0.84 | POLB (0.62) | POLBNAMPTSMN1; SMN2LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313094-A1 | NEW PYRIDINE DERIVATIVES AS LEPTIN RECEPTOR MODULATOR MIMETICS | AstraZeneca AB (SE) | 2011-04-27 | — | — | EP | claimed |
| WO-2009147216-A1 | NEW PYRIDINE DERIVATIVES AS LEPTIN RECEPTOR MODULATOR MIMETICS | BIOVITRUM AB (PUBL) (SE) | 2009-12-10 | — | — | WO | claimed |
| EP-2313094-A1 | NEW PYRIDINE DERIVATIVES AS LEPTIN RECEPTOR MODULATOR MIMETICS | AstraZeneca AB (SE) | 2011-04-27 | — | — | EP | disclosed |
| WO-2009147216-A1 | NEW PYRIDINE DERIVATIVES AS LEPTIN RECEPTOR MODULATOR MIMETICS | BIOVITRUM AB (PUBL) (SE) | 2009-12-10 | — | — | WO | disclosed |