Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 6/20 | 0.35 |
| ▸ | JAK1 | P23458 | 6/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | CEL | P19835 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 2/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16654616 | 0.92 | HTR2C (0.38) | HTR2CJAK2JAK1TYK2JAK3 | |
| SCHEMBL1292240 | 0.80 | ROCK1 (0.32) | ROCK1 | |
| SCHEMBL2040516 | 0.73 | DAO (0.42) | HTR2CCELDAO | |
| SCHEMBL31298942 | 0.72 | KDM4E (0.41) | CELDAO | |
| SCHEMBL18986576 | 0.72 | KDM4E (0.41) | CELDAO | |
| SCHEMBL8139573 | 0.71 | CCNE1 (0.39) | HTR2CJAK2JAK1TYK2JAK3 | |
| SCHEMBL14917598 | 0.70 | JAK2 (0.39) | JAK2JAK1TYK2JAK3KDM5B | |
| SCHEMBL16796830 | 0.68 | DAO (0.45) | HTR2CDAO | |
| SCHEMBL15021016 | 0.68 | GAA (0.54) | JAK2JAK1JAK3 | |
| SCHEMBL4601853 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057586-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015058160-A1 | BROMODOMAIN INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2015-04-23 | — | — | WO | disclosed |