Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 12/20 | 0.66 |
| ▸ | FGFR4 | P22455 | 10/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16656043 | 0.90 | FGFR1 (0.79) | FGFR1FGFR4FGFR3FGFR2CYP3A4 | |
| SCHEMBL19732277 | 0.83 | FGFR1 (0.64) | FGFR1FGFR4LCKFGFR3FGFR2 | |
| SCHEMBL16654577 | 0.79 | FGFR1 (0.75) | FGFR1FGFR4FGFR3FGFR2CYP3A4 | |
| SCHEMBL16655833 | 0.79 | FGFR1 (1.00) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16659496 | 0.75 | FGFR1 (0.65) | FGFR1FGFR4LCKFGFR3FGFR2 | |
| SCHEMBL16659498 | 0.75 | FGFR1 (0.83) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL19732207 | 0.73 | FGFR1 (0.80) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16654074 | 0.72 | FGFR1 (0.75) | FGFR1FGFR4FGFR3FGFR2CYP3A4 | |
| SCHEMBL16656015 | 0.71 | FGFR4 (0.62) | FGFR1FGFR4LCKFGFR3FGFR2 | |
| SCHEMBL16659413 | 0.71 | FGFR4 (1.00) | FGFR1FGFR4FGFR3FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057943-A1 | PYRIMIDINE FGFR4 INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057938-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |