Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 12/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 8/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.55 |
| ▸ | KDR | P35968 | 6/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16894019 | 0.85 | FGFR4 (0.48) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL16665360 | 0.80 | FGFR1 (0.60) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL16071406 | 0.80 | FGFR4 (0.72) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL16176735 | 0.78 | FGFR1 (0.67) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL1521677 | 0.78 | FGFR1 (0.38) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL16176839 | 0.78 | FGFR4 (0.46) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL16176698 | 0.75 | FGFR4 (0.43) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL1521831 | 0.74 | MAPT (0.46) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL15412943 | 0.73 | FGFR4 (1.00) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL15413275 | 0.72 | FGFR4 (0.68) | FGFR4FGFR1FGFR2FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |