Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.52 |
| ▸ | ABL1 | P00519 | 7/20 | 0.52 |
| ▸ | EGFR | P00533 | 7/20 | 0.52 |
| ▸ | HCK | P08631 | 7/20 | 0.52 |
| ▸ | SRC | P12931 | 7/20 | 0.52 |
| ▸ | KDR | P35968 | 7/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.52 |
| ▸ | MTOR | P42345 | 7/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.52 |
| ▸ | PRKDC | P78527 | 7/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 6/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.52 |
| ▸ | BTK | Q06187 | 11/20 | 0.51 |
| ▸ | ATR | Q13535 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16655410 | 0.92 | PIK3CD (0.52) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL16655643 | 0.89 | PIK3CD (0.51) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL16655681 | 0.88 | PIK3CD (0.52) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL23908606 | 0.85 | PIK3CD (0.72) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL16655705 | 0.82 | PIK3CD (0.50) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL16656035 | 0.81 | PIK3CD (0.50) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL23908599 | 0.80 | PIK3CD (0.72) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL23908592 | 0.79 | PIK3CD (0.71) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL23908587 | 0.77 | PIK3CD (0.71) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL16655760 | 0.77 | PIK3CD (0.46) | PIK3CDABL1EGFRHCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057970-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2016-08-24 | — | — | EP | claimed |
| WO-2015058084-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-04-23 | — | — | WO | claimed |