Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 9/20 | 0.78 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.68 |
| ▸ | BTK | Q06187 | 8/20 | 0.68 |
| ▸ | ITK | Q08881 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | HCK | P08631 | 2/20 | 0.54 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.54 |
| ▸ | MTOR | P42345 | 2/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.54 |
| ▸ | PRKDC | P78527 | 2/20 | 0.54 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665681 | 1.00 | ATR (0.78) | ATRPIK3CDBTKITKABL1 | |
| SCHEMBL16655570 | 0.86 | PIK3CD (0.75) | ATRPIK3CDBTKABL1EGFR | |
| SCHEMBL16655682 | 0.86 | ATR (0.82) | ATRPIK3CDBTKPIK3CAPIK3CB | |
| SCHEMBL16665822 | 0.86 | ATR (0.82) | ATRPIK3CDBTKPIK3CAPIK3CB | |
| SCHEMBL16655769 | 0.86 | ATR (0.82) | ATRPIK3CDBTK | |
| SCHEMBL16655293 | 0.84 | PIK3CD (0.72) | ATRPIK3CDBTK | |
| SCHEMBL16655678 | 0.84 | PIK3CD (0.74) | ATRPIK3CDBTKABL1EGFR | |
| SCHEMBL16665677 | 0.84 | PIK3CD (0.74) | ATRPIK3CDBTKABL1EGFR | |
| SCHEMBL16656046 | 0.84 | PIK3CD (0.90) | ATRPIK3CDBTKABL1EGFR | |
| SCHEMBL16655587 | 0.84 | PIK3CD (0.77) | ATRPIK3CDBTKABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057970-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2016-08-24 | — | — | EP | claimed |
| WO-2015058084-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-04-23 | — | — | WO | claimed |
| EP-3057970-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015058084-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-04-23 | — | — | WO | disclosed |