Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.61 |
| ▸ | BTK | Q06187 | 7/20 | 0.61 |
| ▸ | ATR | Q13535 | 2/20 | 0.60 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.53 |
| ▸ | ROS1 | P08922 | 2/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.53 |
| ▸ | CLK2 | P49760 | 2/20 | 0.53 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.53 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | CDC7 | O00311 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16655473 | 0.93 | PIK3CD (0.54) | PIK3CDBTKATRDYRK3CDK1 | |
| SCHEMBL16655942 | 0.85 | PIK3CD (0.53) | PIK3CDBTKATRDYRK3CDK1 | |
| SCHEMBL16655634 | 0.81 | ATR (0.66) | PIK3CDBTKATRDYRK3CDK1 | |
| SCHEMBL16655386 | 0.80 | PIK3CD (0.77) | PIK3CDBTKATRLCKEGFR | |
| SCHEMBL23908617 | 0.79 | DYRK3 (0.48) | PIK3CDBTKATRDYRK3CDK1 | |
| SCHEMBL16654522 | 0.79 | JAK2 (0.62) | PIK3CDBTKATRDYRK3CDK1 | |
| SCHEMBL16655953 | 0.78 | PIK3CD (0.84) | PIK3CDBTKATRSRCKDR | |
| SCHEMBL16655959 | 0.77 | BTK (0.68) | PIK3CDBTKATRLCKSRC | |
| SCHEMBL16655433 | 0.76 | PIK3CD (0.85) | PIK3CDBTKATRSRCKDR | |
| SCHEMBL16665816 | 0.76 | PIK3CD (1.00) | PIK3CDBTKATRSRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES, INC. (US) | 2021-10-14 | — | — | US | disclosed |
| EP-3057970-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015058084-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | BTK, PIK3CD, PIK3CB | PIK3CD 2/4885BTK 1/4885ATR 680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.