Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 7/20 | 0.63 |
| ▸ | FGFR4 | P22455 | 16/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.59 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665299 | 0.85 | FGFR4 (0.64) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL16665308 | 0.85 | FGFR1 (0.62) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL16071492 | 0.85 | FGFR1 (0.82) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL16665345 | 0.85 | FGFR4 (0.53) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL16665333 | 0.81 | FGFR4 (0.50) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL16071598 | 0.81 | FGFR1 (0.70) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL19508322 | 0.78 | FGFR1 (0.63) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL19508052 | 0.78 | FGFR1 (0.63) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL16071681 | 0.78 | FGFR4 (0.72) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL15413202 | 0.77 | FGFR1 (1.00) | FGFR1FGFR4FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |