Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.47 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | CCND1 | P24385 | 2/20 | 0.47 |
| ▸ | CCND2 | P30279 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | WEE1 | P30291 | 6/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12478004 | 0.89 | EGFR (0.43) | BRD4PTK2CDK4CCND1JAK2 | |
| SCHEMBL16656741 | 0.85 | CCND3 (0.47) | BRD4PTK2CDK4CCND1CCND2 | |
| SCHEMBL14643605 | 0.84 | EGFR (0.56) | BRD4PTK2CDK4CCND1CCND2 | |
| SCHEMBL14576358 | 0.82 | PTK2 (0.66) | BRD4PTK2CDK4CCND1CCND2 | |
| SCHEMBL14576373 | 0.72 | PTK2 (0.59) | PTK2 | |
| SCHEMBL4487633 | 0.71 | CDK4 (0.57) | BRD4PTK2CDK4CCND1CCND2 | |
| SCHEMBL17021742 | 0.69 | PTK2 (0.57) | PTK2CCND3CCNA2CDK2CDK9 | |
| SCHEMBL24620370 | 0.69 | ALK (0.61) | PTK2EGFR | |
| SCHEMBL30833050 | 0.69 | ALK (0.61) | PTK2EGFR | |
| SCHEMBL24620195 | 0.67 | ALK (0.58) | PTK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012461-B2 | FAK inhibitors | CANCER THERAPEUTICS CRC PTY LTD (AU) | 2015-04-21 | — | — | US | disclosed |