Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 15/20 | 0.83 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.72 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.63 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16659469 | 0.91 | FGFR1 (1.00) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL582750 | 0.86 | FGFR3 (0.80) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16659464 | 0.84 | FGFR4 (1.00) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16659450 | 0.84 | FGFR1 (1.00) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL19732275 | 0.82 | FGFR1 (0.84) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16659504 | 0.82 | FGFR4 (1.00) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16659425 | 0.81 | FGFR4 (0.77) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16659489 | 0.80 | FGFR1 (1.00) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL374467 | 0.78 | FGFR3 (1.00) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL16665249 | 0.78 | FGFR1 (1.00) | FGFR1FGFR4FGFR3FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057938-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |