SCHEMBL16660396

SCHEMBL16660396

CC(C)Nc1ncc2c(n1)CN(C(N)=O)CC2

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 19/20 0.64
HSP90AA1 P07900 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12497152 0.89 MAPK1 (0.68) MAPK1
SCHEMBL21657108 0.82 MAPK1 (0.53) MAPK1HSP90AA1
SCHEMBL17081723 0.80 MAPK1 (0.72) MAPK1
SCHEMBL17081401 0.79 MAPK1 (0.66) MAPK1
SCHEMBL17081769 0.78 MAPK1 (0.73) MAPK1
SCHEMBL12497804 0.77 MAPK1 (0.66) MAPK1
SCHEMBL12498809 0.77 MAPK1 (0.66) MAPK1
SCHEMBL16649458 0.77 MAPK1 (0.73) MAPK1
SCHEMBL17081420 0.77 MAPK1 (1.00) MAPK1
SCHEMBL16649701 0.76 MAPK1 (0.64) MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2681215-B1 SERINE/THREONINE KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2015-04-22 EP disclosed