Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.39 |
| ▸ | AURKA | O14965 | 4/20 | 0.36 |
| ▸ | BCL6 | P41182 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656863 | 0.82 | SYK (0.43) | SYKAURKABCL6ALDH1A1L3MBTL1 | |
| SCHEMBL654380 | 0.73 | SYK (0.60) | SYK | |
| SCHEMBL656737 | 0.73 | SYK (0.55) | SYKAURKABCL6ALDH1A1L3MBTL1 | |
| SCHEMBL15764450 | 0.73 | SYK (0.47) | SYKBCL6 | |
| SCHEMBL653915 | 0.72 | SYK (0.50) | SYKAURKABCL6ALDH1A1L3MBTL1 | |
| SCHEMBL2102251 | 0.72 | SYK (0.50) | SYKAURKABCL6ALDH1A1L3MBTL1 | |
| SCHEMBL2103491 | 0.72 | SYK (0.54) | SYKBCL6KDR | |
| SCHEMBL656721 | 0.71 | SYK (0.56) | SYKAURKAKDRCDK1 | |
| SCHEMBL656336 | 0.71 | SYK (0.39) | SYKAURKABCL6 | |
| SCHEMBL27612496 | 0.71 | SYK (0.60) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9018204-B1 | 2,4-pyrimidinediamine compounds and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2015-04-28 | — | — | US | disclosed |