SCHEMBL1666348

SCHEMBL1666348

Oc1ccc(Cc2cc([C@@H]3NC[C@H](O)[C@@H](O)[C@@H]3O)ccc2Cl)cc1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 19/20 0.51
SLC5A1 P13866 16/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1033852 1.00 SLC5A2 (0.51) SLC5A2SLC5A1
SCHEMBL16457244 0.84 SLC5A2 (0.59) SLC5A2SLC5A1
SCHEMBL1039664 0.84 SLC5A2 (0.59) SLC5A2SLC5A1
SCHEMBL16457243 0.84 SLC5A2 (0.59) SLC5A2SLC5A1
SCHEMBL28823567 0.74 SLC5A2 (0.50) SLC5A2SLC5A1
SCHEMBL19226959 0.72 SLC5A2 (0.58) SLC5A2SLC5A1
SCHEMBL28823577 0.70 SLC5A2 (0.80) SLC5A2SLC5A1
SCHEMBL19662122 0.70 SLC5A2 (0.58) SLC5A2SLC5A1
SCHEMBL19275060 0.70 SLC5A2 (0.77) SLC5A2SLC5A1
SCHEMBL19275084 0.70 SLC5A2 (0.67) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2308841-A2 Phlorizin analogs as SGLT2 inhibitors Lexicon Pharmaceuticals, Inc. (US) 2011-04-13 EP disclosed