Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.70 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1934861 | 1.00 | BACE1 (0.70) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL1934396 | 0.95 | BACE1 (0.69) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL9888405 | 0.93 | BACE1 (0.68) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL16649390 | 0.93 | BACE1 (0.68) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL7924448 | 0.91 | BACE1 (0.81) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL3302622 | 0.91 | BACE1 (0.81) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL9888443 | 0.91 | BACE1 (0.81) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL9913389 | 0.90 | BACE1 (0.72) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL16664361 | 0.90 | BACE1 (0.82) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL7922541 | 0.90 | BACE1 (0.72) | BACE1BACE2KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332943-B1 | NOVEL FUSED AMINODIHYDROTHIAZINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2015-04-22 | — | — | EP | disclosed |