Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1935779 | 1.00 | BACE1 (0.72) | BACE1KCNH2CYP2D6BACE2 | |
| SCHEMBL9888434 | 0.91 | BACE1 (0.71) | BACE1KCNH2CYP2D6BACE2 | |
| SCHEMBL9888432 | 0.91 | BACE1 (0.71) | BACE1KCNH2CYP2D6BACE2 | |
| SCHEMBL2118794 | 0.90 | BACE1 (0.68) | BACE1KCNH2CYP2D6BACE2 | |
| SCHEMBL2118788 | 0.90 | BACE1 (0.68) | BACE1KCNH2CYP2D6BACE2 | |
| SCHEMBL3300594 | 0.89 | BACE1 (0.77) | BACE1KCNH2CYP2D6BACE2 | |
| SCHEMBL3300597 | 0.89 | BACE1 (0.77) | BACE1KCNH2CYP2D6BACE2 | |
| SCHEMBL9913277 | 0.88 | BACE1 (0.71) | BACE1KCNH2CYP2D6BACE2 | |
| SCHEMBL1933573 | 0.88 | BACE1 (0.81) | BACE1KCNH2CYP2D6BACE2 | |
| SCHEMBL7922416 | 0.88 | BACE1 (0.71) | BACE1KCNH2CYP2D6BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332943-B1 | NOVEL FUSED AMINODIHYDROTHIAZINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2015-04-22 | — | — | EP | disclosed |