⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15606151 | 0.83 | BACE1 (0.30) | — | |
| SCHEMBL16664743 | 0.81 | — | — | |
| SCHEMBL16650249 | 0.79 | BACE1 (0.35) | — | |
| SCHEMBL16650574 | 0.79 | — | — | |
| SCHEMBL16664754 | 0.74 | BACE1 (0.31) | — | |
| SCHEMBL7938915 | 0.74 | BACE1 (0.35) | — | |
| SCHEMBL16650222 | 0.73 | — | — | |
| SCHEMBL16664000 | 0.73 | — | — | |
| SCHEMBL7934136 | 0.72 | BACE1 (0.34) | — | |
| SCHEMBL16650675 | 0.72 | NPC1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855486-B1 | SPIRO TETRAHYDRO-BENZOTHIOPHEN DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | ARES TRADING SA (CH) | 2016-04-06 | — | — | EP | disclosed |
| US-9233982-B2 | Spiro tetrahydro—benzothiophen derivatives useful for the treatment neurodegenerative diseases | ARES TRADING S.A. (CH) | 2016-01-12 | — | — | US | disclosed |
| US-20150111882-A1 | SPIRO TETRAHYDRO - BENZOTHIOPHEN DERIVATIVES USEFUL FOR THE TREATMENT NEURODEGENERATIVE DISEASES | ARES TRADING S.A. (CH) | 2015-04-23 | — | — | US | disclosed |