Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 2/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.47 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 9/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665283 | 0.86 | EGFR (0.49) | MAPK3EGFRFGFR4FGFR1FGFR2 | |
| SCHEMBL20554136 | 0.76 | MAP2K7 (0.54) | MAPK10MAPK8GRM5MAPK3MAP2K7 | |
| SCHEMBL30132615 | 0.76 | MAP2K7 (0.54) | MAPK10MAPK8GRM5MAPK3MAP2K7 | |
| SCHEMBL16665247 | 0.74 | FGFR4 (0.48) | GRM5MAPK3EGFRFGFR4FGFR1 | |
| SCHEMBL16665334 | 0.73 | GCK (0.54) | MAPK3EGFRFGFR4FGFR1FGFR2 | |
| SCHEMBL16665336 | 0.72 | FGFR4 (0.55) | MAPK3FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL23899138 | 0.71 | MAP2K7 (0.59) | MAP2K7EGFRBTKITK | |
| SCHEMBL20554484 | 0.71 | BLK (0.44) | MAP2K7EGFRFGFR4BTKPTPN1 | |
| SCHEMBL30132529 | 0.71 | BLK (0.44) | MAP2K7EGFRFGFR4BTKPTPN1 | |
| SCHEMBL691650 | 0.70 | JAK3 (0.49) | MAP2K7EGFRBTKERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |