Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 8/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665246 | 0.85 | FGFR4 (0.56) | FGFR4MAPK3FGFR1FGFR2FGFR3 | |
| SCHEMBL16665334 | 0.84 | GCK (0.54) | FGFR4MAPK3FGFR1FGFR2FGFR3 | |
| SCHEMBL16665335 | 0.83 | FGFR4 (0.59) | FGFR4MAPK3FGFR1FGFR2FGFR3 | |
| SCHEMBL16665247 | 0.83 | FGFR4 (0.48) | FGFR4MAPK3FGFR1FGFR2FGFR3 | |
| SCHEMBL16665336 | 0.82 | FGFR4 (0.55) | FGFR4MAPK3FGFR1FGFR2FGFR3 | |
| SCHEMBL16665295 | 0.80 | FGFR4 (0.50) | FGFR4MAPK3FGFR1FGFR2FGFR3 | |
| SCHEMBL16665272 | 0.80 | GCK (0.51) | FGFR4MAPK3FGFR1FGFR2FGFR3 | |
| SCHEMBL16665302 | 0.80 | MAPK3 (0.50) | FGFR4MAPK3FGFR1FGFR2FGFR3 | |
| SCHEMBL16665266 | 0.80 | FGFR4 (0.54) | FGFR4MAPK3FGFR1FGFR2FGFR3 | |
| SCHEMBL16665298 | 0.79 | FGFR4 (0.46) | FGFR4MAPK3FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |