Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 12/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665308 | 0.84 | FGFR1 (0.62) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16665333 | 0.84 | FGFR4 (0.50) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL16665390 | 0.79 | FGFR4 (0.38) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL16665345 | 0.75 | FGFR4 (0.53) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL28538295 | 0.72 | FGFR1 (0.61) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16665310 | 0.71 | FGFR4 (0.64) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16656075 | 0.71 | FGFR1 (0.75) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL16071541 | 0.71 | FGFR4 (0.67) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16071893 | 0.71 | FGFR4 (0.62) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16665313 | 0.70 | FGFR4 (0.48) | FGFR4FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |