Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 18/20 | 0.70 |
| ▸ | CDK12 | Q9NYV4 | 17/20 | 0.70 |
| ▸ | CDK7 | P50613 | 16/20 | 0.70 |
| ▸ | CCNH | P51946 | 16/20 | 0.70 |
| ▸ | CCNA2 | P20248 | 12/20 | 0.70 |
| ▸ | CDK2 | P24941 | 12/20 | 0.70 |
| ▸ | CDK9 | P50750 | 11/20 | 0.70 |
| ▸ | CDK13 | Q14004 | 11/20 | 0.70 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.70 |
| ▸ | MNAT1 | P51948 | 10/20 | 0.66 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.66 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.63 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.63 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16655058 | 0.89 | CCNK (0.65) | CCNKCDK12CDK7CCNHCCNA2 | |
| SCHEMBL16655057 | 0.89 | CCNK (0.65) | CCNKCDK12CDK7CCNHCCNA2 | |
| SCHEMBL16655001 | 0.86 | CDK7 (0.92) | CCNKCDK12CDK7CCNHCCNA2 | |
| SCHEMBL16654999 | 0.86 | CDK7 (0.92) | CCNKCDK12CDK7CCNHCCNA2 | |
| SCHEMBL18047433 | 0.83 | CCNK (0.74) | CCNKCDK12CDK7CCNHCCNA2 | |
| SCHEMBL16665751 | 0.83 | CCNK (0.74) | CCNKCDK12CDK7CCNHCCNA2 | |
| SCHEMBL16655207 | 0.82 | CCNK (0.72) | CCNKCDK12CDK7CCNHCCNA2 | |
| SCHEMBL16655209 | 0.82 | CCNK (0.72) | CCNKCDK12CDK7CCNHCCNA2 | |
| SCHEMBL16655206 | 0.82 | CCNK (0.72) | CCNKCDK12CDK7CCNHCCNA2 | |
| SCHEMBL16655208 | 0.82 | CCNK (0.72) | CCNKCDK12CDK7CCNHCCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015058163-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2015-04-23 | — | — | WO | disclosed |