Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | FBP1 | P09467 | 2/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16667301 | 0.91 | DYRK1A (0.48) | EGFRDYRK1AERBB2KDRAURKA | |
| SCHEMBL9901153 | 0.85 | EGFR (0.50) | EGFRDYRK1AERBB2KDRAURKA | |
| SCHEMBL9901558 | 0.82 | DYRK1A (0.56) | EGFRDYRK1AERBB2KDRAURKA | |
| SCHEMBL15348704 | 0.74 | EGFR (0.51) | EGFRERBB2KDRAURKAFBP1 | |
| SCHEMBL9902301 | 0.70 | EGFR (0.57) | EGFRERBB2KDRAURKAFBP1 | |
| SCHEMBL16667191 | 0.70 | EGFR (0.48) | EGFRDYRK1AERBB2KDRAURKA | |
| SCHEMBL16667189 | 0.70 | AURKA (0.48) | EGFRDYRK1AERBB2KDRAURKA | |
| SCHEMBL9905219 | 0.70 | EGFR (0.61) | EGFRERBB2KDRAURKAFBP1 | |
| SCHEMBL9905105 | 0.69 | EGFR (0.49) | EGFRDYRK1AERBB2KDRAURKA | |
| SCHEMBL9902101 | 0.68 | EGFR (0.48) | EGFRERBB2KDRAURKAFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648509-B1 | SUBSTITUTED 4-(ARYLAMINO) SELENOPHENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | KASINA LAILA INNOVA PHARMACEUTICALS PRIVATE LTD (IN) | 2015-04-29 | — | — | EP | claimed |