Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.58 |
| ▸ | CDK2 | P24941 | 3/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.58 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.58 |
| ▸ | ZAP70 | P43403 | 10/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.54 |
| ▸ | PRKCG | P05129 | 3/20 | 0.54 |
| ▸ | PRKCB | P05771 | 3/20 | 0.54 |
| ▸ | LCK | P06239 | 3/20 | 0.54 |
| ▸ | PRKCA | P17252 | 3/20 | 0.54 |
| ▸ | PRKCH | P24723 | 3/20 | 0.54 |
| ▸ | PRKCI | P41743 | 3/20 | 0.54 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.54 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.54 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667266 | 0.93 | EGFR (0.67) | EGFRCDK2JAK2PIK3CAPIK3CB | |
| SCHEMBL1667125 | 0.85 | EGFR (0.55) | EGFRCDK2JAK2PIK3CAPIK3CB | |
| SCHEMBL12276011 | 0.85 | MEN1 (0.56) | EGFRCDK2JAK2PIK3CAPIK3CB | |
| SCHEMBL1670000 | 0.85 | EGFR (0.60) | EGFRCDK2JAK2PIK3CAPIK3CB | |
| SCHEMBL12274953 | 0.84 | EGFR (0.53) | EGFRCDK2JAK2PIK3CAPIK3CB | |
| SCHEMBL1667135 | 0.84 | CDK2 (0.66) | EGFRCDK2JAK2PIK3CAPIK3CB | |
| SCHEMBL12274689 | 0.83 | MEN1 (0.56) | EGFRCDK2JAK2PIK3CAPIK3CB | |
| SCHEMBL12274038 | 0.82 | MEN1 (0.53) | EGFRCDK2JAK2PIK3CAPIK3CB | |
| SCHEMBL1667153 | 0.81 | MEN1 (0.56) | EGFRCDK2JAK2PIK3CAPIK3CB | |
| SCHEMBL13279540 | 0.81 | MEN1 (0.51) | EGFRCDK2JAK2PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488503-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | Myrexis, Inc. (US) | 2012-08-22 | — | — | EP | claimed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | claimed |
| EP-2488503-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | Myrexis, Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |