Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | BMX | P51813 | 1/20 | 0.55 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16670644 | 1.00 | BTK (0.55) | BTKEGFRSRCBMXNR4A3 | |
| SCHEMBL16670742 | 1.00 | BTK (0.55) | BTKEGFRSRCBMXNR4A3 | |
| SCHEMBL16670708 | 0.85 | BTK (0.49) | BTKEGFRSRC | |
| SCHEMBL16670705 | 0.85 | BTK (0.49) | BTKEGFRSRC | |
| SCHEMBL16676695 | 0.85 | BTK (0.49) | BTKEGFRSRC | |
| SCHEMBL16670853 | 0.82 | BTK (0.49) | BTKEGFRSRCBMXNR4A3 | |
| SCHEMBL16670717 | 0.80 | BTK (0.48) | BTKEGFRSRC | |
| SCHEMBL16670872 | 0.74 | BTK (0.49) | BTKEGFRSRC | |
| SCHEMBL20998683 | 0.72 | PARP14 (0.48) | BTK | |
| SCHEMBL18044906 | 0.72 | BTK (0.61) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060550-B1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-05-15 | — | — | EP | disclosed |
| EP-3060550-A2 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | Merck Patent GmbH (DE) | 2016-08-31 | — | — | EP | disclosed |
| WO-2015061247-A2 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2015-04-30 | — | — | WO | disclosed |