Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 6/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 5/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | IDH2 | P48735 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23034 | 0.86 | JAK3 (0.48) | JAK2PTK2CLK1CLK2DYRK1A | |
| SCHEMBL23696 | 0.83 | AURKA (0.52) | JAK2PTK2JAK3AURKAGRM4 | |
| SCHEMBL24629 | 0.80 | IDH2 (0.57) | JAK2PTK2JAK3AURKACTSC | |
| SCHEMBL23189 | 0.80 | IDH2 (0.57) | JAK2PTK2JAK3AURKACTSC | |
| SCHEMBL24034 | 0.78 | IDH2 (0.47) | JAK2PTK2JAK3AURKACTSC | |
| SCHEMBL24622 | 0.78 | IDH2 (0.47) | JAK2PTK2JAK3AURKACTSC | |
| SCHEMBL23674 | 0.78 | IDH2 (0.47) | JAK2PTK2JAK3AURKACTSC | |
| SCHEMBL21053 | 0.75 | JAK3 (0.49) | JAK2PTK2JAK3 | |
| SCHEMBL24621 | 0.75 | MAPT (0.48) | JAK2PTK2JAK3AURKAKDR | |
| SCHEMBL23984 | 0.75 | MAPT (0.48) | JAK2PTK2JAK3AURKAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9023851-B2 | Triazolopyrazine derivatives | MERCK PATENT GMBH (DE) | 2015-05-05 | — | — | US | claimed |