Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 20/20 | 0.54 |
| ▸ | AVPR1A | P37288 | 6/20 | 0.48 |
| ▸ | OXTR | P30559 | 5/20 | 0.48 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.48 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16672282 | 0.91 | AVPR1B (0.44) | AVPR1BAVPR1AOXTRAVPR2 | |
| SCHEMBL15641578 | 0.85 | AVPR1B (0.53) | AVPR1B | |
| SCHEMBL16672232 | 0.82 | KMT2A (0.41) | AVPR1B | |
| SCHEMBL16672251 | 0.79 | AVPR1B (0.50) | AVPR1BAVPR1AOXTRAVPR2 | |
| SCHEMBL1590457 | 0.79 | AVPR1B (0.61) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL5423877 | 0.75 | AVPR1B (0.44) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL1465221 | 0.75 | AVPR1B (0.69) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL6614497 | 0.74 | TSHR (0.40) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL16672308 | 0.74 | AVPR1B (0.57) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL5578368 | 0.73 | AVPR1B (0.66) | AVPR1BAVPR1AOXTRAVPR2GPR65 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9023854-B2 | 5-halogen-substituted oxindole derivatives and use thereof for treating vasopressin-dependent diseases | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-05-05 | — | — | US | disclosed |