Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 4/20 | 0.62 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.46 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.46 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 5/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | ATR | Q13535 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 3/20 | 0.38 |
| ▸ | CHUK | O15111 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99830 | 0.87 | PRKCI (0.62) | PRKCIGRM4AURKBAURKAINCENP | |
| SCHEMBL100052 | 0.87 | PRKCI (0.62) | PRKCIGRM4AURKBAURKAINCENP | |
| SCHEMBL101483 | 0.87 | PRKCI (0.65) | PRKCIGRM4AURKBAURKAINCENP | |
| SCHEMBL29541092 | 0.87 | PRKCI (0.65) | PRKCIGRM4AURKBAURKAINCENP | |
| SCHEMBL20873093 | 0.85 | PRKCI (0.62) | PRKCIGRM4AURKBAURKAINCENP | |
| SCHEMBL101409 | 0.84 | PRKCI (0.56) | PRKCIGRM4AURKBAURKAINCENP | |
| SCHEMBL29540652 | 0.84 | PRKCI (0.56) | PRKCIGRM4AURKBAURKAINCENP | |
| SCHEMBL103041 | 0.84 | PRKCI (0.58) | PRKCIGRM4AURKBAURKAINCENP | |
| SCHEMBL29540955 | 0.84 | PRKCI (0.58) | PRKCIGRM4AURKBAURKAINCENP | |
| SCHEMBL100683 | 0.84 | PRKCI (0.58) | PRKCIGRM4AURKBAURKAINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343298-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2020-05-06 | — | — | EP | disclosed |
| EP-2343298-B1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE CORP (US) | 2015-05-06 | — | — | EP | disclosed |