Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 18/20 | 0.69 |
| ▸ | KCNJ3 | P48549 | 18/20 | 0.69 |
| ▸ | KCNJ5 | P48544 | 13/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4513114 | 0.94 | KCNJ6 (0.72) | KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL1013226 | 0.85 | KCNJ6 (0.61) | KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL23203519 | 0.84 | KCNJ6 (0.65) | KCNJ6KCNJ3KCNJ5NPC1LMNA | |
| SCHEMBL25793174 | 0.84 | KCNJ6 (0.69) | KCNJ6KCNJ3KCNJ5SMN1; SMN2 | |
| SCHEMBL13234482 | 0.82 | KCNJ6 (0.84) | KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL1010934 | 0.80 | KCNJ6 (0.63) | KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL27596969 | 0.79 | KCNJ6 (0.47) | KCNJ6KCNJ3KCNJ5SMN1; SMN2 | |
| SCHEMBL13234475 | 0.77 | KCNJ6 (0.92) | KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL19818825 | 0.77 | KCNJ6 (0.63) | KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL16585546 | 0.76 | KCNJ6 (0.62) | KCNJ6KCNJ3KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268623-B9 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORP (US) | 2018-02-28 | — | — | EP | disclosed |
| EP-2268623-B1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORP (US) | 2015-05-06 | — | — | EP | disclosed |