Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659029 | 0.90 | GCK (0.72) | GCKKCNH2 | |
| SCHEMBL28079725 | 0.90 | GCK (0.72) | GCKKCNH2 | |
| SCHEMBL2658243 | 0.88 | GCK (0.69) | GCKKCNH2 | |
| Bromide SCHEMBL9983508 | 0.87 | GCK (0.68) | GCKKCNH2 | |
| SCHEMBL2669737 | 0.87 | GCK (0.68) | GCKKCNH2 | |
| Bromide SCHEMBL2659082 | 0.86 | GCK (0.67) | GCKKCNH2 | |
| SCHEMBL12021036 | 0.85 | GCK (0.84) | GCKKCNH2 | |
| SCHEMBL2669726 | 0.84 | GCK (0.64) | GCKKCNH2 | |
| SCHEMBL12021669 | 0.83 | GCK (0.72) | GCKKCNH2 | |
| SCHEMBL12021611 | 0.82 | GCK (0.71) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522926-B2 | Activators of glucokinase | METABASIS THERAPEUTICS, INC. (US) | 2016-12-20 | — | — | US | disclosed |
| US-20150119365-A1 | NOVEL ACTIVATORS OF GLUCOKINASE | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2015-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150119365-A1 | NOVEL ACTIVATORS OF GLUCOKINASE | GCKR, GCK, HK1 | GCK 2/4885KCNH2 840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.