Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | CA2 | P00918 | 4/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16677165 | 0.90 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2HPGDCA2 | |
| SCHEMBL15021186 | 0.88 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2HPGDCA2 | |
| SCHEMBL15304618 | 0.87 | SMN1; SMN2 (0.66) | NPC1RAB9ASMN1; SMN2HPGDCA2 | |
| SCHEMBL11936818 | 0.85 | KMT2A (0.66) | NPC1RAB9ASMN1; SMN2CA2ALDH1A1 | |
| SCHEMBL12279683 | 0.85 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2HPGDCA2 | |
| SCHEMBL7207554 | 0.85 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2HPGDCA2 | |
| SCHEMBL23569027 | 0.84 | KMT2A (0.68) | NPC1RAB9ASMN1; SMN2CA2ALDH1A1 | |
| SCHEMBL14386036 | 0.84 | SMN1; SMN2 (0.61) | NPC1RAB9ASMN1; SMN2HPGDCA2 | |
| Hydrochloric Acid SCHEMBL9584772 | 0.83 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2HPGDCA2 | |
| SCHEMBL14271589 | 0.83 | NPC1 (0.75) | NPC1RAB9ASMN1; SMN2HPGDCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160271072-A1 | POLYMER NANOPARTICLES CONTAINING MULTIPLE AGENTS AND METHODS THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2016-09-22 | — | — | US | disclosed |
| US-20160271072-A1 | POLYMER NANOPARTICLES CONTAINING MULTIPLE AGENTS AND METHODS THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2016-09-22 | — | — | US | disclosed |
| WO-2015061468-A1 | POLYMER NANOPARTICLES CONTAINING MULTIPLE AGENTS AND METHODS THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2015-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160271072-A1 | POLYMER NANOPARTICLES CONTAINING MULTIPLE AGENTS AND METHODS THEREOF | LIPA, NPC1, PHOSPHO1 | NPC1 2/4885RAB9A 343/4885SMN1; SMN2 1394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.