Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 8/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 19/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16677271 | 1.00 | PIK3R1 (0.59) | PIK3R1PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL16677722 | 1.00 | PIK3R1 (0.59) | PIK3R1PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL16678027 | 0.93 | PIK3R1 (0.60) | PIK3R1PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL16677382 | 0.93 | PIK3CD (0.54) | PIK3R1PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL16677388 | 0.93 | PIK3R1 (0.60) | PIK3R1PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL16677580 | 0.93 | PIK3R1 (0.60) | PIK3R1PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL16678001 | 0.93 | PIK3CD (0.54) | PIK3R1PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL16677566 | 0.93 | PIK3CD (0.54) | PIK3R1PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL4414626 | 0.92 | PIK3CD (0.53) | PIK3R1PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL31594549 | 0.92 | PIK3CD (0.53) | PIK3R1PIK3CAPIK3CDPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160244452-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS INC (US) | 2016-08-25 | — | — | US | disclosed |
| US-20160244452-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS INC (US) | 2016-08-25 | — | — | US | disclosed |
| WO-2015061204-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2015-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160244452-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | PIK3CA, PIK3CD, PIK3CB | PIK3R1 27/4885PIK3CA 1/4885PIK3CD 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.