Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 11/20 | 0.65 |
| ▸ | ORAI1 | Q96D31 | 6/20 | 0.59 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.45 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6889745 | 0.89 | CRACR2A (0.63) | CRACR2AORAI1KCNJ6KCNJ3MEN1 | |
| SCHEMBL12672291 | 0.89 | CRACR2A (0.63) | CRACR2AORAI1KCNJ6KCNJ3MEN1 | |
| SCHEMBL1883793 | 0.87 | CRACR2A (0.63) | CRACR2AORAI1KCNJ6KCNJ3 | |
| SCHEMBL1879493 | 0.87 | CRACR2A (0.63) | CRACR2AORAI1ALDH1A1 | |
| SCHEMBL1881560 | 0.86 | CRACR2A (0.55) | CRACR2AORAI1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL1667955 | 0.86 | CRACR2A (0.62) | CRACR2AORAI1KCNJ6KCNJ3 | |
| SCHEMBL1879356 | 0.80 | CRACR2A (0.72) | CRACR2AORAI1ALDH1A1MAPT | |
| SCHEMBL1671387 | 0.79 | CRACR2A (1.00) | CRACR2AORAI1KDM4EALDH1A1MAPT | |
| SCHEMBL1668351 | 0.76 | CRACR2A (0.82) | CRACR2AORAI1 | |
| SCHEMBL1878326 | 0.75 | CRACR2A (0.80) | CRACR2AORAI1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509955-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE -ACTIVATED CALCIUM CHANNEL | Rhizen Pharmaceuticals S.A. (CH) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011042797-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE -ACTIVATED CALCIUM CHANNEL | ICOZEN THERAPEUTICS PVT. LTD. (IN) | 2011-04-14 | — | — | WO | disclosed |