Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 18/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15196838 | 0.90 | KCNJ1 (0.74) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL4549644 | 0.87 | KCNJ1 (0.72) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL4549645 | 0.86 | KCNJ1 (0.71) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL2731436 | 0.84 | KCNJ1 (1.00) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL4549629 | 0.81 | KCNJ1 (0.72) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL15191673 | 0.80 | KCNJ1 (0.91) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL16682186 | 0.78 | KCNH2 (0.59) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL4549631 | 0.77 | KCNJ1 (0.72) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL2728757 | 0.76 | KCNJ1 (0.70) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL14785921 | 0.76 | KCNH2 (0.73) | KCNJ1KCNH2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632464-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2015-04-29 | — | — | EP | disclosed |