Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 19/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 16/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4549694 | 0.88 | KCNJ1 (0.69) | KCNJ1KCNH2 | |
| SCHEMBL10286960 | 0.84 | KCNJ1 (0.58) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL10233964 | 0.82 | KCNJ1 (0.77) | KCNJ1KCNH2 | |
| SCHEMBL15196738 | 0.82 | KCNJ1 (0.56) | KCNJ1KCNH2 | |
| SCHEMBL4549652 | 0.81 | KCNJ1 (0.65) | KCNJ1KCNH2 | |
| SCHEMBL4549530 | 0.81 | KCNJ1 (0.82) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL4549662 | 0.81 | KCNJ1 (0.68) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL4549534 | 0.80 | KCNJ1 (0.58) | KCNJ1KCNH2 | |
| SCHEMBL4549529 | 0.80 | KCNJ1 (0.70) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL4549660 | 0.79 | KCNJ1 (0.83) | KCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632464-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2015-04-29 | — | — | EP | disclosed |