Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.77 |
| ▸ | FCER2 | P06734 | 6/20 | 0.77 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.77 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.77 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | DHFR | P00374 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1706131 | 0.87 | SYK (1.00) | SYKFCER2NTRK1NTRK3NTRK2 | |
| SCHEMBL17935542 | 0.87 | SYK (1.00) | SYKFCER2NTRK1NTRK3NTRK2 | |
| SCHEMBL1706133 | 0.87 | SYK (1.00) | SYKFCER2NTRK1NTRK3NTRK2 | |
| SCHEMBL29641275 | 0.87 | SYK (1.00) | SYKFCER2NTRK1NTRK3NTRK2 | |
| SCHEMBL19980736 | 0.77 | SYK (1.00) | SYKFCER2NTRK1NTRK3NTRK2 | |
| SCHEMBL7136077 | 0.75 | SYK (0.78) | SYKFCER2NTRK1NTRK3NTRK2 | |
| SCHEMBL5182676 | 0.75 | NTRK1 (1.00) | SYKFCER2NTRK1NTRK3NTRK2 | |
| SCHEMBL5182671 | 0.75 | NTRK1 (1.00) | SYKFCER2NTRK1NTRK3NTRK2 | |
| SCHEMBL5468658 | 0.75 | NTRK1 (0.72) | SYKFCER2NTRK1NTRK3NTRK2 | |
| SCHEMBL5468662 | 0.75 | NTRK1 (0.72) | SYKFCER2NTRK1NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011045352-A2 | SPLEEN TYROSINE KINASE AND BRAIN CANCERS | NOVARTIS FORSCHUNGSSTIFTUNG (CH) | 2011-04-21 | — | — | WO | disclosed |