Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15662341 | 0.84 | CYP19A1 (0.40) | IDH1NR1I3CHRNB4CHRNA3HRH4 | |
| SCHEMBL23586239 | 0.77 | NR1I3 (0.39) | IDH1NR1I3CHRNB4CHRNA3HRH4 | |
| SCHEMBL15659115 | 0.76 | PDE4B (0.42) | IDH1NR1I3CHRNB4CHRNA3HRH4 | |
| SCHEMBL15947979 | 0.74 | PDE4D (0.44) | IDH1NR1I3KMT2ACHRNB4CHRNA3 | |
| SCHEMBL23586143 | 0.74 | NR1I3 (0.37) | IDH1NR1I3KMT2ACHRNB4CHRNA3 | |
| SCHEMBL23586226 | 0.70 | NR1I3 (0.40) | IDH1NR1I3CHRNB4CHRNA3HRH4 | |
| SCHEMBL10589866 | 0.70 | IDO1 (0.57) | IDH1NR1I3HRH4CYP19A1NPC1 | |
| SCHEMBL6076679 | 0.66 | KDM4E (0.49) | NR1I3CHRNB4CHRNA3MAPTNPC1 | |
| SCHEMBL5732452 | 0.66 | KDM4E (0.49) | NR1I3CHRNB4CHRNA3MAPTNPC1 | |
| SCHEMBL15662301 | 0.66 | CHRNB4 (0.37) | IDH1NR1I3CHRNB4CHRNA3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221843-B2 | Heteroaryl inhibitors of PDE4 | Tetra Discovery Partners, LLC (US) | 2015-12-29 | — | — | US | disclosed |
| US-20150119362-A1 | HETEROARYL INHIBITORS OF PDE4 | Tetra Discovery Partners, LLC | 2015-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150119362-A1 | HETEROARYL INHIBITORS OF PDE4 | PDE4A, PDE4B, PDE4C | IDH1 1604/4885NR1I3 1994/4885KMT2A 2665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.